Contents
List of Symbols
xi
Chapter 1. Bioreaction Engineering: From Bioprocess Design to Systems Biology
1
1.1 The Structure of the Book
3
1.2 Some Comments on Nomenclature used in the Book
7
1.3 A Final Note
8
References
8
Chapter 2. From Cellular Function to Industrial Products
9
2.1 Cellular Growth
10
2.1.1 From Genotype to Phenotype
13
2.1.2 Transport Processes
15
2.1.2.1 Free Diffusion
16
2.1.2.2 Facilitated Diffusion
20
2.1.2.3 Active Transport
22
2.1.3 Catabolism
24
2.1.3.1 Glycolysis
25
2.1.3.2 TCA Cycle and Oxidative Phosphorylation
27
2.1.3.3 Fermentative Pathways
29
2.1.4 Anabolism
30
2.1.5 Secondary Metabolism
35
2.1.6 Secreted Proteins
37
2.2 Biotech Processes - An Overview
37
2.2.1 Strain Design and Selection
38
2.2.2 Fermentation Media
40
2.2.3 Criteria for Design and Optimization
41
2.2.4 Strain Improvement
42
References
45
Chapter 3. Biochemical Reactions
-
A First Look
47
3.1 The Continuous Stirred Tank Reactor
47
3.2 Yield Coefficients
53
3.3 Black Box Stoichiometries
57
3.4 Degree of Reduction Balances
60
3.5 Systematic Analysis of Black Box Stoichiometries
73
3.6 Identification of Gross Measurement Errors
77
Problems
88
References
92
Chapter 4. Thermodynamics of Biochemical Reactions
95
4.1 Chemical Equilibrium and Thermodynamic State Functions
95
4.1.1 Changes in Free Energy and Enthalpy
97
4.1.2 Combustion - A Change in Reference State
102
4.2 Heat of Reaction
103
4.3 Non-equilibrium Thermodynamics
109
Problems
115
References
118
vii
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