Biochemical Reaction Networks
157
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Notice that both the TCA cycle, the glyoxylate shunt and the pyruvate carboxylase are included in the
model, but the matrix still has full rank. This is due to the reaction from 2-oxoglutarate to protein, which
is an additional reaction that imposes a constraint on the flux
via
the TCA cycle.
Glucose
Glucose-6-P---»Carbohydrates
u
Figure 5.5 Simplified metabolic network for
Candida
lipolytica.
Abbreviations:
AcCoA,
acetyl-CoA; OAA, oxaloacetate; CIT, citrate:
ICT, isocitrate; OGT, 2-oxoglutarate;
SUC,
succinate;
MAL,
malate;
GOX, glyoxylate.
Broken lines represent reactions where material
is transported from the cell to the environment,
whereas
solid
lines
represent
intracellular
reactions.
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