9.1.5
Fed-batch Operation
367
9.2 The Plug Flow Reactor
372
9.3 Dynamic Analysis of Continuous Stirred Tank Bioreactors
380
9.3.1 Dynamic Response of the Reactor for Simple, Unstructured Kinetic Models
380
9.3.2 Stability Analysis of a Steady State Solution
388
9.3.3 Dynamics of the Continuous Stirred Tank for a Mixed Microbial Population
397
Problems
409
References
420
Chapter 10. Mass Transfer
423
10.1 Gas-Liquid Mass Transfer
425
10.1.1 Models for
k\
428
10.1.2 Interfacial Area and Bubble Behavior
430
10.1.3 Empirical Correlations for
kta
438
10.1.4 Mass Transfer Correlations Based on Dimensionless Groups
442
10.1.5 Gas-Liquid Oxygen Transfer
448
10.1.6 Gas-Liquid Mass Transfer of Components Other than Oxygen
453
10.2 Mass Transfer to and into Solid Particles
456
10.2.1 External Mass Transfer
456
10.2.2 Intraparticle Diffusion
460
Problems
469
References
474
Chapter 11. Scale-Up of Bioprocesses
477
11.1 Scale-up Phenomena
477
11.2 Bioreactors
478
11.2.1 Basic Requirements and Reactor Types
478
11.2.2 The Stirred Tank Bioreactor
480
11.3 Physical Processes of Importance for Scale-Up
482
11.3.1 Mixing
482
11.3.2 Power Consumption
486
11.3.3 Heat Transfer
491
11.3.4 Scale-Up Related Effects on Mass Transfer
495
11.3.5 Rheology of Fermentation Broths
496
11.3.6 Flow in Stirred Tank Reactors
501
11.4 Metabolic Processes Affected by Scale-up
508
11.5Scale-upinPractice
510
Problems
514
References
517
Contents
ix
Index
519
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