Chapter 6
Benthin, S.
. Nielsen, J., and V illadsen. J. (1993). Transport o f sugars
two anom er-specific sites on the mannose-
phosphotransferase system in
L a cto c o ccu s crem oris: in vivo
study o f mechanism , kinetics and adaptation.
B iotechnol.
B io en g
42, 440-448.
Com ish-Bow den.A . (1995). "Fundam entals o f Enzyme K inetics" , Portland Press, London (UK).
Delgado, J.P and Liao, J.C. (1991). Identifying rate-controlling enzym es in metabolic pathways w ithout kinetic parameters.
B io tecn o l.P ro g .
7, 15-20.
Delgado. J.P. and Liao, J.C. ( 19 9 2 a). D eterm ination o f flux control coefficients using transient m etabolite concentrations.
B iochem . J._
282, 919-927.
Delgado. J.P. and Liao, J.C. ( 1992b). M etabolic control analysis using transient m etabolite concentrations. Determ ination o f
m etabolite concentration control coefficients.
B iochem . J
282, 919-927.
Delgado, J.P.
. M eruane.J., and Liao, J.C. (1993). Experimental determ ination o f flux control distribution in biochem ical systems
in vitro
model to analyze m etabolite concentrations.
B io tec h n o l B io en g .41^
121-1 128.
Ehlde. M.
. and Zacchi. G. (1996). Influence o f experim ental errors on the determ ination o f flux
control coefficients from
transient m etabolite measurements.
B iochem .
7 313,721-727.
Fell. D. (1997), "U nderstanding the C ontrol o f M etabolism ” . Portland Press, London (UK).
Flint, H.J.
. Tateson, R.W ., Barthelm ess, I.B., Porteous, D.J., Donachie, W.D., and Kacser, H. (1981). Control o f the tlux in the
arginine pathway o f
S e u ro sp o ra crassa. B io ch em J
200, 231-246.
Gram. J.
. de Bang, M., and Villadsen, J. (1990). An automated glucose- isom erase reactor system with on line flow injection
analyzers for m onitoring o f pH, glucose- and fructose concentrations.
C hem . Eng. Sci,
45, 1031-1042.
Levenspiel, O. (1999). “Chem ical Reaction Engineering” 3.rd edition. W iley, New York.
Liao, J.C., and L ig h tfo o t, E.M. (1988). C haracteristic reaction paths o f biochem ical reaction systems with time scale separation.
B io tec h n o l B io en g
31, 847-854.
M elchiorsen, C.R., Jensen, N.B.S., C hristensen, B., Jokum sen, K.V., and Villadsen, J. (2001). D ynamics o f pyruvate metabolism
L a cto co ccu s laciis. B iotechnol. B ioeng.
74, 271-279.
Nordkvist. M. (2001). "Physiology o f Lactic A cid Bacteria”. M.Sc. thesis , Biocentrum , DTU, Denmark.
Nielsen. J., Jorgensen, H. S. (1995) M etabolic control analysis o f the penicillin biosynthetic pathway in a high yielding strain of
P enicillium ch ryso g en u m , B iotechnol. P rog.
Small. J.R. and Kacser, H. (1993). Response o f metabolic systems to large changes in enzym e activities and effectors.
Eur. J.
B iochem .
213, 613-640.
Stephanopolous, G., and Vallino, J.J. (1991) Network rigidity and metabolic engineering in m etabolite overproduction.
252, 1675-1681.
Stephanopolous. G., A nstidou. A.A., and Nielsen, J. (1998). "M etabolic Engineering”. A cadem ic Press, San Diego (USA).
W ei, J.
. and Prater, C.D. (1962). "The Structure and Analysis o f Complex Reaction System s”, in
A d va n ces in C a ta lysis
13 203-
W esterhoff, H.V. and Chen, Y.-D.( 1984). How do enzyme activities control metabolite concentrations. An additional theorem in
the theory o f m etabolic control.
Eur. J. B iochem .
W esterhoff. H.V., and Kell, D.B. (1987). M atrix method for determ ining steps m ost rate- limiting to m etabolic fluxes in
processes B io tec h n o l B io e n g
30 101-107.
previous page 257 Bioreaction Engineering Principles, Second Edition  read online next page 259 Bioreaction Engineering Principles, Second Edition  read online Home Toggle text on/off