524
Index
maintenance 127, 131,348
two compartment model for 271-274,353
Lactobacillus casei
127
Lactococcus cremoris'.
see also
Lactococcus lactis
requirement of ATP for growth 30, 129
RNA content 267
structured model 271-274
Lactococcus lactis
shift in metabolic product 396
Lacoperon 280
Lag phase: see Growth rate equations
Lipid: see also Fat(s) 16-18,156
in
E. coli
24-25, 32, 127-129, 133, 174-177
in metabolic flux analysis 153, 156-159, 174-177
lipopolysaccharide 32
in
E. coli
32
neutral fat 55
transport across lipid membrane 16,18,20
Logistic law 250
Lotka Volterra equation for prey predator interaction 404
Luedeking and Piret equation
lactic acid production by
Lactococcus delbruekii
130
Macromixing: see Mixing, macromixing
Macromolecule 11
elemental composition 55
Macroscopic morphology: see Morphology
Maintenance 18,20,69, 122, 125-126, 128, 130-138, 175,308
influence on cell recirculation reactor 361-363,414
kinetics in batch culture 348-350,416
kinetics in continuous culture 254-256, 356-359, 391,
416
Mass transfer 7, 16,67,339-340,423-430
gas liquid mass transfer 52, 88-89, 364-366, 415, 511-513
of other components than oxygen 453-456
of oxygen 448-453,473
volumetric mass transfer coefficient (definition) 427
scale up 495-496
mass transfer into solid particles 456
external 456-460
intraparticle diffusion 460-469,472
regimen analysis of the penicillin fermentation 511
Matching law model: see Cybernetic model
Mean residence time 429
Mean Sauter diameter 431,434-435
Medium 4,6-7,11
coalescence 435,451,505
complex 32,40-41,49, 127, 129-131, 148, 191,204,236
containing filamentous microorganisms 499
defined 32,41,236
methods for characterization of mixing 485
rheology 496-500,515
stirrer design 439,515
viscous 432,439,443,452,499
mixing 452
resistance to bubble formation 432
Membrane: see Cell membrane
Messenger RNA: see RNA
Metabolic control analysis 5,189-190,207-233
branched pathway 221
concentration control coefficient 213
elasticity coefficient 214
flux control (sensitivity) coefficient 211-212
flux control summation theorem 212
Metabolic engineering 1-4,42^15, 151, 170, 184,221-222,478
Metabolic flux analysis 5,44,120-122,151,153
citric acid fermentation 156
heterofermentative metabolism of lactic acid bacteria 148-151,
ISO
of aerobic
S. cerevisiae
138-142
of anaerobic
S. cerevisiae
143-148,179
of solvent fermentation 181-184
propane 1,3-diol fermentation 184-186
using linear programming 171-178
Metabolism 5, 11,35
citric acid fermentation 67
of
Clostridium acetobutylicum
181,187
heterofermentative 148
secondary 35-36
Metabolite
growth with metabolite formation 25, 123-124
primary 29
secondary 12
Methane 62,415,479
aerobic growth of
Methylococcus capsulatus
65-66, 365, 414-
416
as product from C02 and H2
as substrate for production of single cell protein 412,414-416,
513
from
Methanobacterium ihermoputotrophicum
107
heat of combustion 104
Henry’s constant for 426
reduction of carbon dioxide 65,72, 107-109
Michaelis Menten equation 190-194
variants of 195-201
Micromixing: see Mixing, micromixing
Microscopic morphology: see Morphology
Mitochondria: see Phosphorylation oxidative
Mitosis in cell cycle for budding yeast 294
Mixed acid fermentation 29,148-150,181,396
Mixed cultures
as a result of infection 390-391
competition between prey and predator 404
competition between two microorganisms 397-401
reversion of a desired mutant 402
Mixed substrate: see also Diauxic growth
cybernetic model for growth on 277,313-314
Mixing 4,339-340,370,433,481-486,504,508-511, 516-518
different stirrer design for 482
tn regimen analysis of the penicillin fermentation 511
macro mixing 483
micromixing 483,486
mixing time in (ideal) bioreactors 339-340,483,491,496
visualized by computational dynamics (CFD) 500
Monod equation/model 246
estimation of parameters 236-237,306
and external mass transfer 456-458
with inhibition by substrate or product 345-348,354,356-
358,389-391,393
model for growth of filamentous fungi 291, 294,302-303
model for growth of
S. cerevisiae
256-261
Monod kinetics including maintenance 254-255
structured models 251-253. 268-269. 276 284-285 303
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