Index
525
growth of filamentous microorganisms 302
morphologically structured models 291,302,303-306
population balance for hyphal elements of filamentous fungi
330-335
Mother cell: see Yeast budding
mRNA: see RNA, mRNA
Mutant: see Mutation
Mutation
colonial mutants 294
competition between two microorganisms 390,399-404,416
description of spontaneous occurrence of mutants 294
in obtaining control coefficients 222-223
improved penicillin production 42-43
Mycelium 300-301
breakage of mycelium 331
rheological properties of medium containing 499
NADH, NAD+, NADPH, NADP+; see Nicotinamide adenine
dinucleotide
Networks of zones models 503-504
Nicotinamide adenine dinucleotide
NADH
conversion to NADPH 61,92,117
conversion to NAD+ in respiration 27-28,109-111
degree of reduction 61
determination of, using a cyclic enzyme
assay 205-206
formation i n b iom ass productio n 132-133
role in glycerol production 144
NADH and FADH2
in TCA cycle 28
in respiration 27,110
NADPH
conversion to NADH 61,92,117
lumping with NADH 61,137, 138-148
production in PP pathway 26,133
requirement in biomass production 132-133
requirement in
E. coli
32
requirement in lysine production 180
Newtonian fluid 496-497
Non Newtonian fluid 497
Bingham fluid 498
Casson fluid 498
power law model for viscosity of 498, 500
Pseudoplastic fluid 498-499
Non-observability: see Observability
Nuclear magnetic resonance (NMR) 166-167
Nusselt number 492
Observability 150
Operator 79, 279-282,284,308-309,460
in a model for diauxic growth 281,284
of the lac operon 280
Oscillations 48,295-299
criteria for oscillations in a chemostat with one
microorganism 390,392
in a chemostat with a mixed microbial population 405-406,
416-417
of predator prey interactions 405-406,416-417
of yeast cultures 295,297-298
Over-determined system: see Error diagnosis
Oxidative phosphotylation: see Phosphorylation, oxidative
Oxygen
consumption 54,128-129, 133
aerobic growth 64-66
citric acid production by
Aspergillus niger
71 -72
E. coli
176-177
propane 1,3-diol 184-185
penicillin production by
Pénicillium
chrysogenum
90,472
single cell protein production 65-66,89-90,414-415
S. cerevisiae
67-71, 138-140,370-371
determination of oxygen in biomass 88
diffusion coefficient 452,454-455, 471-472
diffusion into a pellet of
Pénicillium chrysogenum
472
dissolved oxygen concentration 88-89,425,448-453,470-473
fermentations with mammalian cells 470
laboratory bioreactor 428,449
pilot plant bioreactor 471
production of single cell protein 425
spontaneous oscillations of yeast cultures 295
Henry’s constant 426
in compartment model for 5.
cerevisiae
508-509
maintenance requirement 128, 138, 175
operational P/O ratio 128, 133-135, 137-138
regimen analysis of the penicillin fermentation 511
requirement
different organisms 254
yeast culture 425,490
respiratory chain 27, 136, 142
specific uptake rate 18,68, 88,175-177,202,256-260,449
transport 16, 18,26, 109-110,423-424, 506
into a single cell 447
into pellets 472
volumetric mass transfer coefficient 365,371 447,471, 513
empirical correlations 430,439
in a laboratory bioreactor 439,449,490
measurement 449-453
Parasite: see Parasitism
Parasitism 401
Partitioning function: see Filamentous microorganism,
Peclet number 443, 445
Penicillin
critical dissolved oxygen concentration 474,516
design of pilot plant bioreactor for production of 512
determination of kia in a bioreactor for producing 469-472
increase in productivity 41-43
production of 9,19,35-36,38-39,41-43,48, 53,90
yield coefficients for NADH/NADPH 133
Pénicillium chrysogenum:
see Filamentous microorganism,
P.
chrysogenum
Pentose phosphate pathway/PP pathway 25
Permeability coefficient 17-19
PH
auxostat 49
difference over cell membrane 113
gradient in the proton motive force 112-113
influence on
transport of organic acids 18-20
growth kinetics 261-264
citric acid fermentation 71-72
lactate fermentation 18,130,411
COj uptake 453-454
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