526
Index
thermodynamic reactions 103-104
uptake of NH3 59-60
method for determination of mixing time 485,516-517
Phase plane plot 395,405-408
Phosphorylation
oxidative 27,109-110,129
substrate level 127,129
Phosphotransferase system (PTS) 16
uptake of glucose in
E. coii
24
Plasma membrane: see Cell membrane
Plasmid
copy number, and stability of 288-290,292,325-330,401 -
402,416
flow cytometry for measuring plasmid DNA 321
in age distribution model for
S. cerevisiae
326
loss of plasmid 324,329
modeling of recombinant £
coli
288
Cornell model 289-290
population balance 323
Plug flow reactor see Bioreactor, tubular
P/O ratio
definition 28
operational 111, 114, 127-128, 132-133, 135-142,185
Polyhydroxybutyrate (PHB) 57,91
Population balance 315-318
age distribution model of 5.
cerevisiae
326
general form 316
hyphal elements of filamentous fungi 330
plasmid content in recombinant
E. coli
323
size distribution of
Schizosaccharomyces pombe
320
Power input/dissipation/consumption
correlations involving power input 432-434,436,438,440,
486-489
in bubble size determination 436-437
in kia determination 438-439, 515
in mixing 486-489
Power law-
model 498-499
index 498-499
Power number 487-491
for different stirrer designs 488
Prandtl number 493
Precursor 11-12,25,27,30
for synthesis of cell material 120
in antibiotics 35,39,90
Procaryotes 301
sugar transport by PTS system 23
fermentative pathways for (Fig, 2.6 A, B) 29
proton transport of oxidative phosphorylation in 112
transhydrogenase taken from Azeobachter 92
Product formation stoichiometry : see Stoichiometry
Product yield: see Yield coefficient
Promoter
in a model for diauxic growth 285
in inducible plasmids 279-280
of the lac operon 280
Protein 2-3,10
as a biomass component 32,55,266,268,513
as a foam stabilizing compound 435
catabolite activator protein (CAP) 282
Cornell model 290
dénaturation of 96,262
elemental composition 55,136
in£.
coli
14,24,30,32,39,262,266,279-281,286,288
in metabolic flux analysis 156
in ribosomes 266
in
S. cerevisiae
10, 14,37, 39, 55,57,260-261
in structured model 251,268-269,281,289-291
in uptake of ions 24
measurement by flow cytometry 321
number of molecules per cell 281
produced by protein synthesizing system (PSS) 31,287-288
recombinant 10,37, 39,43, 260-261,286-289,326
repressor 279-282,286,288-289
single cell (SCP) 10,53,57,65,365
bioreactor design 415,513
use of methane for production of 65,513
use of methanol for production of 65, 513
use of ethane for production of 89
synthesis model 268-269,281,286-288
ribosomal 266
transportby 14-15,22,24
Proton transport 18,20,24, 113
Pseudosteady state 5
intracellular metabolites 15, 100,119-124, 134,142,151-152,
155-156,205
mass transfer processes 16,423-425,448-449,453,456,460,
511
of ATP 12, 22-28, 30-34, 62-63,,99-100,109-112, 161, 175-
177
pathway intermediates 100-101, 148-149,163,201,212-215
Pseudoplasticity 498
Quasistationarity: see Pseudosteady state
Reaction limited regime 458
Recirculation of biomass
in a stirred tank reactor 359-364
in a plug flow reactor 372,418-420
Recombinant: see Protein, recombinant
Redundancy: see Error diagnosis
Regimen analysis 511,518
Repression/repressor 286,288-289
in
E. coii
model 308-309
model for diauxic growth 281,284,
of lac operon 280
Respiratory chain: see Phosphorylation, oxidative
Respiratory quotient (RQ)
aerobic growth with NH3 as N-source 64
definition 54
for growth of
S. cerevisiae
with ethanol formation 70-71
without ethanol formation 69
Response coefficient (in MCA) 228
Reynolds number 442-443,445, 501,510
for stirring 442,487, 490
of gas stream at the orifice of a sparger 437
Rheology of fermentation media 499,515,518
Ribonucleic acid: see RNA
Ribosome 267,287,313
in protein synthesis model 290
in structural models 290.313
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