Index
527
in
E. coli
32
in lactic bacteria 266
mRNA 15
rRNA 266-267
Saccharomyces cerevisiae:
see Yeast
Saturation constant
in allosteric enzymes 201
in Michaelis Menten kinetics 191
in Monod model 246
oxygen uptake by
S. cerevisiae
449
values for sugars in different microorganisms 247
Scale up 2-3,7,477-478,482,510-512
effects on
metabolic processes 508-509
mixing time 339,379,491,496, 509-510,514,517-518
mass transfer 495-496
reactor to surface area 493
Schmidt number 443
Secondary metabolite 12,35-37
influence of morphology 312,334,338
Luedeking and Piret model for production of 130, 187
penicillin 9, 19-20,35-36,38-39,41-43
Septum: see Filamentous microorganism
Shear stress
definition of
for bubbles 432
for liquid flow 496-498
onhyphae 331
Shear rate
definition 496
effect on hyphae 331-332
Sherwood number 443
mass transfer into a single cell 445
Single cell protein: see Protein, single cell
Solubility
of carbon dioxide 16,425,427
ofoxygen 16,425,427,448,450-451,513
partitioning coefficient 16
Specific growth rate
definition 53
general calculation of 242-245
in black box model 245-246,252
influence of temperature and pH 261-263
Statistical theory of turbulence 432433
Stability
asymptotic 389
conditional 399
of a microbial strain 294,416
Stirred tank reactor: see Bioreactor
Stirring
influence on kia 439-442,490
influence on mixing 483488
power input 439,441442,486488,490,493-494, 515
Stochastic model 238,281
Stoichiometry
biochemical reaction networks
aerobic processes 132-142
in simple networks 142-150
black box model 57-60,73-77
morphologically structured model 291-292
pathway reactions 63
stoichiometric matrix 122-123
Stokes law 459
Storage carbohydrates: see Glycogen and Trehalose
Subapical compartment: see Filamentous microorganism
Substrate level phosphorylation: see Phosphorylation, substrate
level
Superficial gas velocity
definition of 436
upper limit of 482
use in correlations 436,438,441442,498
Synchronous culture 295,312
Systems biology 14,7-8
TCA cycle 27-28, 132-133, 171, 178, 185
anaplerotic pathways 34,154,156
energetics of aerobic processes 132
in metabolic flux analysis of citric acid fermentation 155
Teissier model: see Growth rate equations, unstructured
Temperature
influence on growth kinetics 261-263
influence on oxygen solubility 448
Thermodynamic efficiency 28,109, 111, 114-115,142
Thiele modulus 464466
generalized 468-469
Tip extension: see Filamentous microorganism
Transport process
active transport 22-24,114-115
facilitated diffusion 20-22
free diffusion 16-20
See also: Mass transfer and Cell membrane, active transport
Trehalose
in
S. cerevisiae
57
Tricarboxylic acid cycle: see TCA cycle
Turbulence
isotropic turbulence 433-434
statistical theoiy of 432433
turbulence models 482, 504
Turnover
of ATP 31,34, 100, 124-126, 128
of macromolecules 126,128,269
of mRNA 126, 128,285-286
of NADH and NADPH 34, 124-125
Uncorrelated measurements 82-83
Unstructured model 238-240
for growth 245-253
alternatives to the Monod model 251
black box model 245-246,252-253
Monod model 246-249
Variance covariance matrix: see Error diagnosis
Viscosity
for fluids 496-498
definition 443,459, 486
in dimensionless groups 443
in medium containing filamentous fungi 460
influence on volumetric mass transfer 439
resistance to bubble formation 431432
Volumetric mass transfer coefficient
definition 427
Wall growth
filamentous fungi 300-301
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